Pyrazoline derived Thiazolidinone Derivatives

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 

Check Your Delivery Options

 
Rs. 3,718

Availability: In stock

 
  • Product Description
 

Angiotensin II receptor antagonists, also known as angiotensin receptor blockers (ARBs), AT1-receptor antagonists or sartans, are a group of pharmaceuticals which modulate the renin-angiotensin-aldosterone system. These substances are AT1-receptor antagonists – that is, they block the activation of angiotensin II AT1 receptors.Blockade of AT1 receptors directly causes vasodilation,reduces secretion of vasopressin, reduces production and secretion of aldosterone, amongst other actions – the combined effect of which is reduction of blood pressure. Irbesartan molecule has pyrazolidinone structure and many thiazolidinone derivatives, are reported for their interesting profile of activities. As these two compounds could prove isosteric with the moiety present in Irbesartan, we thought it is worthwhile to condense these two moieties and form their Mannich bases as the resultant compound may act as angiotensin II antagonists. For this reason Mannich bases were prepared and evaluated for their activity.

Product Specifications
SKU :COC77758
AuthorNaveen Kadian and Prerna Pujari
LanguageEnglish
BindingPaperback
Number of Pages100
Publishing Year2014-05-27T00:00:00.000
ISBN9783659548185
Edition1 st
Book TypeChemistry
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
0 Review(s)