Pyrimidine-Clubbed Schiff’s base possess biological and Pharmaceutical activity such as antibacterial, anti-fungal, anti-tubercular, anti-mycobacterial, anti-inflammatory and antioxidant activity. In this book, we have reported how to synthesize compounds bearing Pyrimidine Schiff’s base. All the novel reported compounds were characterized by elemental analysis, FT-IR, 1H NMR and Mass Spectroscopy. These compounds were found to be very good antibacterial and anti-fungal activities. This book is useful for any researcher of chemistry, pharmacy or related disciplines who are familiar with synthesis of organic moieties.