Quality of life (QoL) for people with schizophrenia has been a focus of concern in order to improve their standard of life to lead to more satisfaction, happiness, and well-being. However, few studies have examined the QoL for people with schizophrenia in Arab countries and none have solely studied the QoL for people with schizophrenia in Saudi Arabia. This work investigates the QoL for Saudi Arabian people with schizophrenia. It is driven by research questions regarding Saudi Arabian people with schizophrenia’s level of satisfaction with their QoL, as well as how they perceive their QoL. It provides basic information about the Saudi Arabian health care system, schizophrenia and QoL concept. Further, the research gives a detailed review of previous literature on the relationship between schizophrenia and patients’ perceptions of QoL. It reports on the QoL for Saudi Arabian people with schizophrenia through the use of mixed methods and compares the results with the QoL for people with schizophrenia in previous studies. This study’s findings provide an important basis for Saudi Arabian mental health care services, mental health nursing practice and education, and future research.