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Quinoline fused Benzimidazoles and their Pharmacological Evaluations

 

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  • Product Description
 

The present book describes the one pot route for quinoline fused azeto[1,2-a]benzimidazole derivatives, involving condensation of o-phenylenediamine with 2-chloroquinoline-3-aldehydes and subsequent Pd-catalyzed cross coupling of resulting benzimidazole N‒H with 2-choloroquinoline leading to the formation of four-membered azetidine ring as a key step. Synthesized analogs were further tested for antimicrobial, antimycobacterial and anti-prostate cancer activity to observe the variation in biological activity. The bioassay results revealed that the majority of final analogs exhibited potential bio efficacies with the remarkable level of MICs comparable to control drugs. Considering the excellent reaction efficiency, wide substrate scope and very mild reaction conditions, the mentioned synthetic protocols may be attractive routes for the synthesis of other heterocycles. It is worth concluding that insertions of various functional groups are essential to increase the different pharmacological activities of the resultant scaffolds by lowering the MICs in all the cases evaluated. In short, our findings might be beneficial as leads to designing new potential bioactive agents.

Product Specifications
SKU :COC77663
AuthorAmit Patel,Kishor Chikhalia and Premlata Kumari
LanguageEnglish
BindingPaperback
Number of Pages68
Publishing Year2014-09-30T00:00:00.000
ISBN9783659614408
Edition1 st
Book TypeChemistry
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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