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Radiobiology of Malignant Melanoma


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  • Product Description

The goals of the present work are to evaluate the sensitizing/protective effect of melanin in the cytotoxicity and genotoxicity of ionizing radiation, including induced oxidative stress modulation in malignant melanoma cells in presence and absence of melanin, and to interpret obtained results in the perspective of melanoma or other malignancies radiotherapy. The biological effects of ionizing radiation interaction are explored with special focus on the biologic effects of radiation in normal and melanoma cells and the interaction of melanin with the damage caused by ionizing radiation (IR). Melanin is a class of pigments present in almost all living beings. Melanin protection against UV radiation is widely acknowledged, but not completely understood; some recent studies claim that melanin can also play an in important role in protection against ionizing radiation. However, other studies evidenced that melanogenesis may be a source of reactive substances, some of them carcinogenic. This study is an attempt to clarify which behavior prevails in IR-exposed cells.

Product Specifications
SKU :COC29756
AuthorSérgio Fonseca,Margarida Goulart de Medeiros and Célia Gomes
Number of Pages84
Publishing Year2012-06-01T00:00:00.000
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-29 00:00:00
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