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Recent Advances in Chordoma

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Chordoma is a rare malignant bone tumour, showing notochordal differentiation and occurs in the axial skeleton. Brachyury, a molecule involved in notochordal development, is a highly specific and sensitive marker for chordoma. It is hypothesised that brachyury or genes involved in its activation are implicated in the pathogenesis of chordoma. As there is no effective drug therapy for chordoma, the aim was to identify genetic events involved in chordoma pathogenesis with a view to identifying potential therapeutic targets. PI3K/AKT/TSC/mTOR pathway was found activated in 65% of chordomas, thereby providing a rationale for testing mTOR inhibitors for the treatment of selected cases. The fibroblastic growth factor receptor pathway was activated in more than 90% of the analysed cases. Nearly half of the cases showed chromosomal abnormalities involving the brachyury locus. Knockdown of brachyury gene was achieved, for the first time, in the U-CH1 chordoma cell line using shRNA and resulted in premature cell senescence. EGFR copy number gain was detected by FISH in 45% of chordomas. The EGFR inhibitor, tyrphostin (AG1478) significantly inhibited growth of the chordoma cell line.

Product Specifications
SKU :COC94730
AuthorAsem Shalaby
LanguageEnglish
BindingPaperback
Number of Pages160
Publishing Year2011-09-29T00:00:00.000
ISBN978-3844394771
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00
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