The global economy is not able to face the crisis' impact. This is why the economists try to find new solutions and approaches, in order to support the economic recovery and to continue the economic sustainable development. Maybe the best solution is the regional approach. There are a lot of definitions of the regions and more and more approaches of them. The present book realizes a synthesis of those approaches as a first step to a deeper analysis of the regional socioeconomic development. A distinct part of the book analyses the most important regional models used by the decision makers in order to support their political interventions. Moreover, the author propose new static and dynamic regional models able to offer new possibilities of analysis to the decision makers. Last but not the least, the book realizes dynamic comparative analyses between EU28 Member States. The analysis and the conclusions of every chapter are supported by the latest official statistic data, pertinent diagrams and tables.