Call Us 080-41656200 (Mon-Sat: 10AM-8PM)
Free Shipping above Rs. 1499
Cash On Delivery*

Regulation of ribosome biogenesis and RNA polymerase I transcription

 

Marketed By :    Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 

Check Your Delivery Options

 
Rs. 5,886

Availability: In stock

 
  • Product Description
 

Ribosome synthesis depends on nutrient availability sensed by the target of rapamycin (TOR) signaling pathway in eukaryotic cells. TOR inactivation affects ribosome biogenesis at the level of RNA polymerase I (Pol I)-dependent transcription of ribosomal RNA (rRNA) genes, expression of ribosomal proteins (r-proteins) and ribosome biogenesis factors, pre-ribosome processing, and transport. Detailed analysis shows that upon TOR inactivation the levels of newly synthesized ribosomal subunits drop drastically before the integrity of the Pol I apparatus is severely impaired but in good correlation with a sharp decrease in r-protein production. Inhibition of translation by cycloheximide mimics the rRNA maturation defect observed immediately after TOR inactivation. Both cycloheximide addition and the depletion of individual r-proteins also reproduce TOR-dependent nucleolar entrapment of specific ribosomal precursor complexes. The conclusion could be drawn that shortage of newly synthesized r-proteins after short-term TOR inactivation is sufficient to explain most of the observed effects on ribosome production.

Product Specifications
SKU :COC97488
AuthorRobert Steinbauer
LanguageEnglish
BindingPaperback
Number of Pages148
Publishing Year2011-06-06T00:00:00.000
ISBN978-3838126142
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandNot defined
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-18 00:00:00