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Reproductive Toxicology

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Andrographis paniculata (AP) has selected to be developed as an anti-diabetic herbal extract. However, the adverse effect of AP on male reproductive function is still unknown. The present study aims to look at the effects of 50% AP ethanolic extract (APE) on the male Sprague Dawley rats’ reproductive functions and to see whether it has anti-fertility effects. Four important endpoints were observed i.e. male reproductive performance (MRP), male sexual behavior (MSB), histological toxicity evaluation of male reproductive organs and hormonal level. Sixty adult male rats aged 8-10 weeks were used in this study. Five groups were administered with APE at doses of 0.5, 1.0, 10, 100 and 1000 mg/kg for not less than 77 days by oral gavaging. MRP remained unaffected and no toxicity effects were observed. The treatment of APE of up to 1000mg/kg neither induce any significant changes in sexual behavioral parameters nor changes of body, reproductive organs and other internal organs weights. APE treatment effect showed no anti-fertility or toxic effects to male reproductive functions. APE seems, therefore, to be safe for rats.

Product Specifications
SKU :COC36486
AuthorSul'ain Mohd Dasuki,. Syed Mohsin and . Hasnan
LanguageEnglish
BindingPaperback
Number of Pages224
Publishing Year2012-06-04T00:00:00.000
ISBN978-3848496785
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00