The changing needs in the population and the growing health-concern that is germinated in today’s society have led to healthier lifestyle practices. People consume healthy and balanced diets and participate in various kinds of activities from mainstream exercises to sport and wellness centers. Likewise, tourists seek to participate in activities that improve their health and well-being, including visits to health and spa centers at a particular holiday destination. It argues that a deep understanding of consumers profiles and their key motivations is vital in sustaining the growth of health and spa tourism business. This monograph highlights the qualitative study on tourists’ motivational factors of using health and spa facilities in five-star resorts.