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Reticulocytosis as a Surrogate Marker of Recent Pf Malaria Infection


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  • Product Description

Reticulocytosis is an important previously unappreciated surrogate marker of recent Plasmodium falciparum reticulocyte parasitation. Evidence from studies in murine and primate models show increased prevalence of Plasmodium falciparum parasitisation of reticulocytes. The increase in reticulocyte infection has been attributed to compensatory reticulocytosis and increased parasite densities. However, the prevalence of P. falciparum parasitisation of reticulocytes in human populations in holoendemic areas of malaria is unknown. Therefore, the current study examined the prevalence of P. falciparum parasitation of reticulocytes and its association with clinical, parasitological and haematological outcomes in children and adults with acute P. falciparum malaria and healthy malaria -ve controls from a holoendemic area of malaria of western Kenya.Results of this study demonstrate higher prevalence of reticulocyte parasitation in children. Thus, it seems likely that P. falciparum reticulocyte parasitation leads to a burst in compensatory reticulocytosis in acute paediatric malaria predictable by HDP and a febrile illness among children

Product Specifications
SKU :COC97807
AuthorPatrick Okoth
Number of Pages116
Publishing Year2011-08-24T00:00:00.000
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-18 00:00:00