Rheumatoid Arthritis among South Asian and Caucasian Populations of the East Midlands in the UK


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  • Product Description

A comparative study of eight candidate genes in the two ethnic groups with Rheumatoid Arthritis. The study of eight genes, relevant to Rheumatoid Arthritis in the South Asian and Caucasian patients and the non-affected matched ethnic siblings and controls, residing in the East Midlands of the UK is fully encompassed in the book. The disease, treatment with currently available drugs and the genetic basis, including the aetiology of the disease is explained. The raison d''être for studying VDR BsmI, FokI, TNFR2, A2M, GSTT1, GSTM1, CRHRA1, CRHRA2, FcgRIIIA and ACE genes, and the association analysis with the disease is fully covered. Significant genetic associations were observed with TNFR2, A2M, and GSTT1 among Caucasians and with VDR BsmI, A2M and GSTT1 in South Asians. In the majority of cases, recessive and multiplicative modes of inheritance explained the observed associations. The hypothesised roles of these genes in sustaining and progressing RA is also discussed, with reference to the role of free radicals formed by infective agents. That ethnicity affects the genetic associations in RA is well highlighted in the book.

Product Specifications
SKU :COC94341
AuthorANANT GHELANI,Sarabjit Mastana and Ashok Samanta
Number of Pages276
Publishing Year2011-06-07T00:00:00.000
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandVDM Verlag Dr. Müller
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00
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