Rice polishings is rich source of the protein, carbohydrates and vitamins with better nutrients density and amino acids profile as compared to cereal grains. Due to presence of 13-15% good quality oil in it many solvent extraction plants have come up to extract rice polishings oil as food or industrial oil. So a huge quantity of defatted rice polishings (DRP) is available as poultry feed ingredient. Its full nutritional potential cannot be utilized due to association of some anti-nutritive factors like phytates, trypsin inhibitor, hemoagglutins-lectin and adulteration of crude fiber during rice milling process. A series of studies were conducted to disassociate the toxic factors by chemical i.e. 0.4N HCl, 0.2N NaOH, 6% H2O2 and 0.1 % Kemzyme HF?as well as physical treatments like extrusion cooking to enhance the nutritive value of defatted rice polishings for its higher level of inclusion in broiler feed. The improvements after treatments were achieved by breaking bonds of complex carbohydrates and elimination of toxic proteins like trypsin inhibitor, lectin etc. Therefore, the digestibility, NPU, PER, PD etc of treated DRP was increased than the untreated defatted rice polishings.