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Role of Adaptor Proteins in Pancreatic Cancer


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Pancreatic ductal adenocarcinoma remains a major unsolved health problem, with conventional cancer treatments having little impact on disease course. In the present work we describe use of a Sos-recruitment system-based yeast two hybrid screen to identify protein interactions involving proteins that are expressed in pancreatic cancer cell lines. Using a yeast two-hybrid approach, we have identified proteins that interact with these adaptor proteins. Among them we have found several molecules that modulate cell proliferation and survival (CIZ1, BIRC6, RBBP6), signaling (LTBP4, Notch2, TOM1L1, STK24) and membrane dynamics (PLSCR1, DDEF2, VCP). Several proteins that nteract with (Vav2, ITSN1, Stac) are known to function in vesicle trafficking, endocytosis and other regulatory processes.

Product Specifications
SKU :COC60962
AuthorMuhtadi Suliman
Number of Pages264
Publishing Year29.05.2014
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-05 00:00:00