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Role of Ceramide In The Inhibition of Rat Chemical Hepatocarcinogenesis


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Ceramide are family of lipid molecules. Ceramide consist of a Long-chain or Sphingoid base linked to a fatty acid via an amide bond. Ceramide has emerged as a key regulator of a wide spectrum of biological processes such as cellular differentiation, proliferation, programmed cell death (PCD), and apoptosis of cells. Cell proliferation studies were carried out in chemically induced rat hepatocarcinogenesis. Immunostaining of PCNA, Ki-67 and BrdU results revealed that, Group C rats showed a minimal PCNA expression, decrement in ki-67 expression and Low BrdU labeling suggesting the suppressive potential of Ceramide. DNA Damage and DNA protein cross link results revealed that, length and width ratio of DNA masses and Tailed cells were better in group C than that of Group B. Chemopreventive effect of Ceramide in apoptosis, study indicates a significant increase in the apoptotic labeling index in the Group C compared to that of group B as documented by TUNEL assay. Histochemical and Histopathological results suggested that,liver weight,GGT-Positive foci andtumor incidence were better in group C than Group B.Ceramides were shown a promising chemopreventive potential against hepaticcancer.

Product Specifications
SKU :COC31291
AuthorRangasamy Manivannan
Number of Pages92
Publishing Year7/18/2012
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00