Autoimmunity is physiological condition with uncontrolled and excessive production of antibodies. Such uncontrolled production of antibodies are the result of excessive release of chemical mediators of inflammation specially cytokines. The autoantibody plays a sinister and pivotal role to induce several autoimmune diseases which make one’s life difficult and arduous. Present work is an attempt to underline the role of cytokine to show their negative importance. Furthermore, the book provides safe immune depressant plant drugs which might help either to treat or to stop the progress of such untreatable disease.