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Role of gene fusion in evolution of restriction-modification enzymes


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The discovery and the investigation of restriction-modification enzymes have been having enormous impact on development of modern biology through applications of the recombinant DNA technology. In corresponding databases the number of potential proteins assigned to type II restriction enzymes alone is beyond 10 000, which probably reflects the high diversity of evolutionary pathways. Their classification includes many subtypes with highly varied properties. Type IIC organises bifunctional endonuclease-methyltransferase enzymes and currently consists of 12 described members. Here it is presented experimental evidence that a new type IIC restriction and modification enzymes carrying both activities in a single polypeptide could result from fusion of the appropriate genes from preexisting bipartite restriction-modification systems; and found 76 new potential bifunctional restriction-modification enzymes by computer analysis of genomic data. Finally, it is proposed a molecular mechanism of appearing of type IIC restriction-modification and M.SsoII-related enzymes, as well as other multifunctional proteins.

Product Specifications
SKU :COC86999
AuthorDmitri Nikitin
Number of Pages56
Publishing Year2013-03-20T00:00:00.000
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00