It is well recognized that chronic psychosocial stress suppresses both cellular & humoral immune responses rendering susceptible to different diseases. Dysregulated corticosterone release has been implicated as the mediators of immune suppression in psychological stress. Significant elevation of plasma dopamine in chronic psychological stress is evident & dopamine mediated functional suppression of T cells has been shown by us, therefore the significance of dopamine (DA) in regulation of the immune effector cells were explored in psychological stress. So, considering the cancer caregivers as a model of chronic psychological stress, we investigated the significance of plasma DA in the regulation of T & B cell functions. Irrespective of age & sex, the plasma DA in < 80% of cancer caregivers were significantly elevated. The circulating lymphocytes were also functionally depressed in these patients. The level of DA found in cancer caregivers when added to in vitro culture of lymphocytes, found inhibition of T & B cells proliferation & cytokines release. So, DA mediated suppression of T & B cells can be alleviated in the clinics by modulating DA receptors present on lymphocytes.