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Role of PPAR agonist in Cerebral Ischemia Reperfusion Injury

Role of PPAR agonist in Cerebral Ischemia Reperfusion Injury

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Objective: Present study was designed to investigate effect of gemfibrozil on I/R. Experimental: I/R in rats were induced by bilateral carotid artery occlusion (30 min) and followed by reperfusion (2 hrs). Results and Discussion: Gemfibrozil treated rats demonstrated significant reduction in infarct sizes (P < 0.05) when compared with I/R group of rats, suggested that gemfibrozil markedly attenuated I/R injury. Gemfibrozil treatment demonstrated a significant decreased in malondialdehyde (P < 0.01), and significant increased was observed in level of reduced glutathione (P < 0.01), superoxide dismutase (P < 0.05) and catalase (P < 0.01). Gemfibrozil treatment resulted significant increased in level of Na+-K+ ATPase (P < 0.05) and Mg+2 - ATPase (P < 0.01) and significant reduction of Ca+2 - ATPase (P < 0.01) when compared with I/R group of rats. Conclusion: In conclusion, gemfibrozil attenuated the cerebral ischemia – reperfusion injury and prevention is being shown via membrane stabilization, reducing the oxidative stress, and preventing apoptotic cell death.

Product Specifications
SKU :COC31168
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31
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