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Role of Surfactant protein D in Chronic Obstructive Pulmonary Disease


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The study describes the link between serum levels of surfactant protein D, its genetic polymorphisms and risk of Chronic Obstructive Pulmonary Disease. Single nucleotide polymorphisms has been genotyped using PCR and restriction analysis. Serum SP-D levels were measured using a specific immunoassay. Autoantibodies including anti dsDNA, antinuclear and antinucleosome antibodies levels were also recorded. It was found that allele ‘A’ at rs3088308 (p=0.000, B=-0.399) and ‘C’ allele at rs721917 (p=0.021; B=-0.344) were associated with significantly low serum SP-D levels. Additionally allele ‘T’ at rs721917 was significantly associated with risk of COPD (p=0.042). Haplotype ‘A C’ (A in rs3088308 and C in rs721917) was under-represented in cases as compared to controls (p=0.005). The results showed that exacerbation status is a significant determinant of serum SP-D even after adjusting for genetic factors. This study reports for the first time that rs3088308 is an important factor influencing systemic SP-D levels and confirms the association of rs721917 with risk of COPD and serum SP-D levels. In addition, the protective effect of haplotype ‘A C’ against COPD was also revealed.

Product Specifications
SKU :COC84547
AuthorTania Shakoori and Abdul Rauf Shakoori
Number of Pages116
Publishing Year2013-07-06T00:00:00.000
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00