The success of endodontic therapy depends on the eradication of microbes from the root canal system and prevention of reinfection. For complete sterilization of the root canal, chemical debridement in the form of irrigation is a must in combination with mechanical instrumentation. Sodium hypochlorite is still the most widely used irrigating solution in endodontics. This book gives an insight into the method and instruments of irrirgation, various properties of each irrigating solution, mode of action of irrigation solution, selection of irrigant solution, problem in irrigation and new modalities of irrigation. This book is very useful for both the undergraduate and the postgraduate students as it gives a clear idea as to which irrigating solutions can be used to achieve the best results. It will help the practioners do a successful treatment of endodontically diseased tooth in every aspect.