The study was designed to evaluate the cardioprotective potential of Saraca indica (SI) herb extract on the basis of biochemical, electrocardiographic and histopathological parameters in cyclophosphamide (CP) induced myocardial toxicity. Cardiotoxicity was induced in rats by administering cyclophosphamide (200 mg/kg, i.p.) single injection. SI (200 and 400 mg/kg, p.o.) were administered immediately after administration of cyclophosphamide on first day and daily for 10 days. The general observations, ECG, Level of biomarkers, serum enzymes, Lipid profiles, antioxidant enzymes, level of myocardial infarction & Histopathological changes were estimated. The Reports indicates that Saraca indica treatment produced dose dependent protective effect in ameliorating the biochemical, histopathological and electrographic abnormities caused by CP administration.