Urinary schistosomiasis is a parasitic disease that is caused by Schistosoma haematobium which usually cause bilharziasis. Due to the biological association of the organism with man in contact with water bodies and poor sanitation systems, the people in Upper Manya Krobo District suffer different kinds of signs and symptoms such as anaemia, abdominal pains, painful urination and bilharziasis with increasing infection each year. Due to the problems in the district, this research was conducted to investigate the prevalence of the infection in 2010/2011 and also to investigate how it affects the various age groups, the respective communities and sex groups in the District. The outcome indicated that there was an increase in prevalence by (25.52%) compared with 7.09% in the previous year. This indicates more than a tripling of the previous prevalence. This outcome would help the various health sectors in Ghana the need to deliver good medical care to the communities that are closer to water bodies in the regions of the country.