Different endocrine biomarkers have been recognized to influence body composition and body fat distribution. One of the most important manifestations of hormonal control over body composition is the role of sex hormones in regulating the secretion and sensitivity of ghrelin and leptin. Both; ghrelin and leptin act in a complementary manner, signaling the metabolic balance and managing the neuroendocrine and metabolic response to feeding and starvation. Consequently, ghrelin and leptin signaling systems influence partitioning and depositing excess nutrients into adipocytes. Little is known about the effect of the integrative association between serum estrogens, ghrelin and leptin levels on the homeostasis of body weight, body composition and body fat distribution in obese and non-obese females.