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Self Emulsifying Drug Delivery System


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Solubility is considered as a great problem for Ibuprofen hence a solubility enhancing technique, Self-emulsifying drug delivery system (SEDDS), was considered to be developed for Ibuprofen. Capmul PG 8 was used as a co-solvent. As surfactant, hydrophilic surfactant Cremophor EL was considered. A fixed amount of Ibuprofen was added with fixed amount of excipients. Capmul PG8 showed a good solubilizing capacity which dissolved 300 mg/ml of Ibuprofen. Cremophor EL also showed a good solubilizing capacity which dissolved 300 mg/ml of Ibuprofen. A 3-level factorial design was carried out to optimize the formulation. The optimized formula contains 24.10 mg Capmul PG8 and 71.02 mg Cremophor EL which releases 27.78%, 44.6% and 74.24% ibuprofen at the mentioned time interval. The present study shows that the Capmul PG8 and Cremophor EL have increased the release profile of capsule Ibuprofen. This attempt, therefore, delivers an alternative strategy in drug product formulation for poorly water soluble drugs. Pharmaceutical technologists, Pharmacists will find it a fruitful approach specially those working on drug delivery.

Product Specifications
SKU :COC31270
AuthorMd. Ismail Hossain and Sadika Akhter
Number of Pages88
Publishing Year7/16/2012
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00