Self-nanoemulsifying drug delivery systems (SNEDDS) have been proved as technologically worthwhile, effortlessly scalable and economically sound delivery systems for enhancing the oral bioavailability of highly lipophilic drugs. Distinct merits of smaller globule size, higher solubilization tendency and robust formulation advantages have made them as one of the most promising alternatives among the diverse lipid-based nanostructured systems. In the last two decades, the phenomenal success of SNEDDS as a potential delivery platform for oral delivery of drugs has gained phenomenal interest in academia and industry with utility of them in non-oral drug delivery too. The current book manuscript provides an overview account on the recent advances in the development of self-nanoemulsifying formulations along with their characterization and applications in enhancing biopharmaceutical performance of the drugs. Besides, the book highlights two research case studies as instances to the pharmaceutical formulation scientists for development of solid self-nanoemulsifying systems of two poorly water soluble drugs, ondansetron and valsartan, for enhancing their oral bioavailability.