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Self Microemulsifying Drug Delivery System For Some Drugs


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

BCS class II are poorly water soluble and some drugs have high molecular weight, more than eleven hydrogen bond acceptors, more than five hydrogen bond doner. Thus, it exhibits poor bioavailability. A new Solid-Self Emulsifying Drug Delivery System (S-SMEDDS) of Drugs has been successfully developed to enhance its oral bioavailability by improving its solubility and facilitating high molecular weight of Drugs absorption. The primary composition of SMEDDS formulation was selected from solubility, pseudoternary phase diagram, emulsifying efficiency and compatibility test for preparation of (L-SMEDDS). Drug loaded L-SMEDDS were prepared in different concentration of oil, surfactant/co-surfactant and optimized by various evolutionary parameter such as robustness to dilution, drug content, ultrasonic interferometer, ease of emulsification, droplet size and in vitro diffusion study. The optimized L-SMEDDS converted into free flowing granules by spray drying technique. S-SMEDDS powder undergoes for characterization and confirmed the no interaction between drug and excipients.Thus, the present investigation improved the oral bioavailability of Drugs.

Product Specifications
SKU :COC76797
AuthorVikrant Wankhade
Number of Pages280
Publishing Year2014-09-05T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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