Interaction has been considered as one of the most important activities in human’s life from the antiquity to the modern times. The revolution of information technology has led to the emergence of electronic interaction that involves machines to support and facilitate humans' interaction. Though the research on electronic interaction has achieved large advances in the last decades, there are still critical and challenging problems especially with regards to semantic interaction. Namely, little attention has been paid to devise technology that reflects humans’ natural interaction. Humans need a smart technology that reasons and acts on behalf of them and, consequently, minimize their effort. In order to reflect the human natural interaction, one core problem to face is the semantics in human interaction. In this work, we study the semantics enabled interaction. Our ultimate goal is to develop a technology that maximizes the reflection of human natural way of interacting. We present a theory of the semantic enabled interaction by capturing its definition, procedure and semantics.