This research was focused on the prevalence and significance of HPV types in cervical cancer in Chennai, South India. The study was carried out by analyzing HPV by PCR in the biopsy of cervical cancer patients. The molecular pathogenesis of HPV was analyzed by correlating the data with the expressions of different cell cycle associated molecules such as p53, bcl-2 and PCNA in the biopsy. The data was also correlated with the level of ATRA in the serum of cervical cancer patients.The highlight of the research findings are:i)Carcinogenic high risk HPV types 16 and 18 are more prevalent in Tamil Nadu (Chennai),India. ii)HPV infection establishes its carcinogenicity through altered cell cycle control molecules such as p53, bcl-2 and PCNA iii)Retinoid ATRA level has a major role during carcinogenesis and it was found to be associated with the oncopotency of HPV types. Hence,the research Concludes that Uterine cervical cancer is more prevalent in Chennai, India and it is highly associated with the oncogenic HPV types 16 and 18.