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Silymarin protection role in modulating ribavirin genotoxicity

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

?Hepatitis C virus (HCV), first described in 1989, is now ?recognized as one of the main causes of chronic liver disease ?worldwide. HCV infection becomes chronic in the majority of ?cases. All current treatment protocols for hepatitis C are based ?on the use of interferon alpha and ribavirin (RBV). Despite RBV broad spectrum in treatment ?of various viral infections, recently several reports revealed ?genotoxic effects of RBV in vivo and in vitro. This genotoxicity ?was correlated with the production of reactive oxygen species ??(ROS).? ?This study aimed to evaluate RBV genotoxicity and ?investigate the role of the natural antioxidant silymarin (SL) to ?modulate RBV genotoxicity.? In the present study, RBV was injected i.p. at three dose ?levels either as a single injection or multiple injections for 5 consecutive days. Other groups were treated with SL (70 ?mg/kg)1hr before RBV injection. Mice were sacrificed at different ?sampling time after RBV treatment. ?Micronucleus (MN) and SSCP assays were used as cytogenetic assay and molecular end point to assess genotoxic ?and cytotoxic effects of RBV and to evaluate SL pretreatment ?protection effect.?

Product Specifications
SKU :COC41766
AuthorNahed Hussien
LanguageEnglish
BindingPaperback
Number of Pages172
Publishing Year4/30/2012
ISBN978-3659113741
Edition1 st
Book TypeGenetics (non-medical)
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-03-08 00:00:00