CAN is serial communications protocol which efficiently supports distributed real time control with very high level of security. CANoe v7.6 which is the product of a German company Vector is a practical and powerful tool for system design and analysis of CAN networks and others (FlexRay, LIN,etc.). Firstly, a design scheme of simulation and test system for vehicle body CAN bus network is brought forward, which mainly includes the topology of network, the hierarchical model of network and the selection of bus baud rate. Secondly, a method of how to use CANoe to construct the simulation and test environment for vehicle body CAN bus system is implemented. Finally, the simulation and test system for vehicle body CAN bus is completed by CANoe v7.6. The results are also be verified on FlexDevel board. The FlexDevel boards consist of MPC5567 chip and many input ports and output ports. Experiments that are done demonstrate that the development method of simulation and test system is feasible.