Chromatography is a modern tool of analysis. In practice, quantifying an analyte in a complex sample becomes an exercise in problem solving. To be efficient and effective, an analytical chemist must know the tools that are available to tackle a wide variety of problems. Analytical chemistry requires broad background knowledge of chemical and physical concepts. Studying the fundamental concepts will reinforce our understanding of both the analytical techniques and the underlying principles. An attempt has been made to understand the concept of simultaneous estimation of drugs in combination for NSAID category. Paracetamol and Nabumetone are widely used drugs having significant Analgesic and Antipyretic activity. They are key ingredients of many popular generic and branded drugs available worldwide.