Different attempts are made in the past, and the efforts are still going on HIV/AIDS prevention and impact mitigation programs. Development agencies nowadays have made use of a range of strategies to create self sustaining economic base for the economically vulnerable groups of PLWHA. These development agencies are increasing their emphasis on assisting the economically vulnerable group to secure livelihood through income generating activities. The finding depicts that PLWHA not participating in IGA faced financial constraints to cover their household expenses in comparison with those participating in IGA. Given the small amount of financial resources as well as inadequate technical supports, IGA have reduced the economic burden of PLWHA of those implementing it. However, challenges were also identified in which reduced the efficiency of the program. Major challenges were identified by the researchers are financial support for IGA is inadequate, inadequate IGA skill trainings, stigma and discrimination and less technical support were identified as major challenges.