HIV/AIDS epidemic has become a global crisis affecting all levels of society. It is an urban threat that affects the civil servants uniquely. The social and economic consequences of the epidemic are having an impact on civil servants, institutions and on the development of the town. All the civil servants and their institutions are faced social and economic problems by the epidemic. The objective of the study is to reveal that the social and economic impacts of HIV/AIDS on civil servants of Wukro town in Tigray, Ethiopia. Therefore, the analysis will help the individuals, institutions and policy makers to understand the socioeconomic impacts of HIV/AIDS on civil servants, so as to forward or plan the possible measures to reduce these impacts on the development.