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Solid Dispersion Of Aceclofenac And B-Cyclodextrin Complex


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Aceclofenac is an effective analgesic and anti-inflammatory drug prescribed widely in recent years for various types of pain and inflammation. Aceclofenac is partially insoluble in water and aqueous fluid and as such it exhibits poor variable oral bioavailability. Aceclofenac needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. Among the various approaches to enhance the solubility and dissolution rate of poorly soluble drugs complexation with cyclodextrin is an effective and industrially accepted technique. In the present investigation, Complexation of aceclofenac with ?-CD was carried out by using various techniques like physical mixture, kneading method, co-precipitate method & solvent evaporation method. From the various characterization studies like drug content, production yield & in vitro dissolution study. Data were further treated with statical analysis using ANNOVA model and from the result of statical analysis batch abc-6 by kneading method was selected as optimised batch. Optimised batch was also studied for FTIR and DSC studies.

Product Specifications
SKU :COC31284
AuthorKhushal Dhamat,Nirmal Shah and Chirag Bhalala
Number of Pages92
Publishing Year7/13/2012
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00