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Solubility enhancement by Solid Dispersion Technique

Solubility enhancement by Solid Dispersion Technique

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 
₹ 3,651

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  • Product Description
 

Bicalutamide is poorly soluble drug which is non-steroidal androgen having pKa 12. Aqueous in vitro solubility of bicalutamide is low at 50 ?g/mL at pH 7 and 37°C. The drug exhibits low bioavailability related to its poor water solubility. Therefore, bicalutamide bioavailability can be improved by increasing its solubility. Solid dispersion technique is most effective technique to improve solubility of drug. Solid dispersions of bicalutamide were prepared by using solvent evaporation technique using HPMC and surfactant like SLS. Solubilities were calculated by using In-vitro dissolution technique. 1:4 drug: HPMC ratio was found efficient with 2% SLS concentration. Using this solid dispersion tablet was formulated and evaluated. In evaluation it was found that Bicalutamide showing 97.251% release at 120 min which is higher than standard drug.

Product Specifications
SKU :COC31301
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31
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