Large areas of the Gatumba Mining District in Rwanda are covered by Technosols (pegmatite or pegmatite-soil mixtures) resulting from coltan mining activities. These substrates are poor in soil plant nutrient contents and are low in soil productivity. Due to agricultural land shortage in Rwanda, almost all the available land is farmed. The present study was conducted to evaluate the effect of tithonia and inorganic fertilizers on plant nutrient uptake and biomass production of soybean grown in Gatumba soils that are affected by the previous coltan mining activities. A greenhouse pot experiment and a field trial were conducted using pegmatite substrate alone and pegmatite-Lixisol Bt mixture. Soybean biomass, grain yield as well as its total N, P and K were measured at harvest while soil total nitrogen (N), available phosphorus (P), potassium (K) and carbon (C) were analyzed before and after the trials. The results demonstrate that soybean DM, grain yield, N, P and K accumulation were higher on pegmatite than on the mixture.The technosol materials showed great agricultural potential which could be positively exploited if their storage capacity of nutrient and water is improved.