This book is designed for specially structured flow shop scheduling problems which are more close to real world industry. In the modern era of globalization a cut throat competition an edge in the business, industries depends upon multitude of factors with the sole purpose of maximization of profit and minimization of cost. With the resources being limited the emphasis lies on finding out a best way for effecient utilization of resources. Scheduling is a key factor to solve the problem. Scheduling is the allocation of resources over time to perform a collection of task. It is an important subject of production and operations management area. In flow-shop scheduling, the objective is to obtain a sequence of jobs which when processed in a fixed order of machines, will optimize some well defined criteria. We consider the important concepts transportation time, weightage of jobs which shows relative importance of a job over another job.