Weeds pose serious threat to wheat productivity, and chemical means are mostly employed to tackle these. Three commonly available broad-spectrum herbicides, i.e., Pallas 45OD (pyaxosulam), Atlantis 3.6WG (iodo + mesosulfuran-methyle) and Affinity 50WP (isoproturon + carfentrazone ethyl ester) were evaluated in three genotypes viz., Sehar-2006, Lasani-2008 and AARI-2011.A herbicide tank mixture comprising of Axial 0.5EC (pinoxaden, ) and Buctril Super 60EC (bromoxynil, + MCPA) was also included. Weed free and weedy check plots were also included for comparison. Despite the increased availability of superior wheat genotypes over time, average national wheat yield is still stagnant and outcomes of wheat breeding programs have not been fully realized yet. A number of biotic and abiotic factors pose threat to higher wheat productivity under field conditions. Among these, weeds are the serious biological constraints that limit wheat production. There is ever growing concern that genotypic variation responsible for weed tolerance can be exploited as an integral component of integrated weed management program.