Under five child mortality is a factor that can be associated with the safety of the population and taken as one of the development indicators of health and socioeconomic status. This study show that there is disparity of under five child mortality rate from region to region in Ethiopia. The main objective of this study was to investigate the existence of regional heterogeneity in under five child mortality and identify important determinant of under five child mortality in Ethiopia. In order to meet the objective of this study standard logistic regression and multilevel logistic regression models were used. This study has revealed that sex of the child, family size, education level of mother, age at first birth of mother, breast- feeding, using contraceptive method and region of child were found to be significant determinants of under five child mortality in Ethiopia. The multilevel logistic model provided interesting relationships that would not be evident from a standard logistic model. There is a variation of under- five child mortality from region to region and there is a variation of under five child mortality within regions.