A number of chemical agents have been identified to cause genotoxic effects in cells producing clastogenic, teratogenic, mutagenic and carcinogenic effects at different dosage of administration. A number of counter toxicity principles have been identified and their mode of action studied. Although some studies are available on antigenotoxic potential of plant products, few studies are available on anti-genotoxic principles in steroid-induced genotoxic effects in human cells in vitro and in vivo. Present study, therefore, is directed towards investigation of the antigenotoxic action of some natural products in steroid-induced genotoxic damage in human lymphocytes in vitro, and, in mice in vivo. The aim of the present work is to study the genotoxic effects of steroids on human chromosomes in vitro, to score the observations with the administration of anti-mutagens in vitro and in vivo both synergistically as well as in isolation, and, to develop models of anti-mutagen-steroid interactions in inducing anti-mutagenicity from dose-time dependent relationship and suggest reaction mechanisms involved.