The growing emphasize by Organizational Development (OD) practitioners to focus upon ‘Strategic Business Model’ of the company has been the prime reason to choose strategy-OD alignment as topic of this book. The need to align HR strategy with overall organization strategy has resulted voluminous knowledge in the area of organization design and change. This requires a synthesis to formalize the knowledge. The present dissertation works upon two primary research themes. Firstly, It identifies predominant strategy orientations / types viz. Defender & Innovator from available literature, and attempts to match them with selected Organization Development (OD) interventions for static and transformational changes. An independent field study is also included here as separate to describe opposing cultural orientations. A proper understanding of loose and tight culture not only facilitates in rating the cases understudy but the investigation also gives deep understanding of soft organizational variable before selecting OD interventions. The qualitative study builds case when exploration and exploitation activities takes place under different roof.