Call Us 080-41656200 (Mon-Sat: 10AM-8PM)
Free Shipping above Rs. 1499
Cash On Delivery*

Strategies to improve omeprazole solubility and permeability

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 

Check Your Delivery Options

 
Rs. 5,886

Availability: In stock

 
  • Product Description
 

The buccal mucosa is an alternative route for oral administration of drugs that show a strong first passage hepatic metabolism and high sensitivity to acidic environment in stomach, allowing improvement of its bioavailability. Nevertheless, administration of drugs in the buccal mucosa is limited due to its low permeability. Unlike that of the small intestine, the mucosa of the oral cavity has a stratified squamous epithelium with 20 to 40 layers of cells that act as a barrier against endogenous alterations and exogenous substances that reach the oral cavity. In addition, for an effective administration of drugs in the oral mucosa, it is necessary to increase the time of contact between the oral mucosa and the administered pharmaceutical form. From these characteristics, the objectives of this study are to increase the model drug (omeprazole) stability and solubility in the oral cavity environment (saliva), and simultaneously to use strategies to increase the drug absorption through the buccal mucosa.

Product Specifications
SKU :COC95165
AuthorAna Figueiras and Francisco Veiga
LanguageEnglish
BindingPaperback
Number of Pages296
Publishing Year2011-11-29T00:00:00.000
ISBN978-3844331929
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00
0 Review(s)