Fighting against plant diseases, including those caused by fungal pathogens, has been a major challenge to plant breeders. Fungal pathogens contribute a huge yield-loss worldwide. Improving the plant genome by introducing novel antifungal genes has become a promising strategy. This book begins with an over view of plant disease resistance; plant arsenal itself has provided a number of transgenes that enhance disease resistance. This book consolidates various strategies that are exploited to enhance resistance against fungal diseases in plants. These strategies involve deploying candidate genes from plant’s own defense machinery or from non-plant resources. Drawbacks of these strategies are also discussed. The details of various fungus-resistant transgenic plants obtained using these transgenes are summarized.