Stress is our body’s physical and emotional reaction that frightens, irritate, confuse, endanger, or excite us and place demands on the body. It is increasing due to globalization and economic crisis, which affects all professions, and as well as families and societies, almost all countries of the world. If stress remains untreated, can lead to a variety of stress related illnesses such as hypertension, heart disease, anxiety, depression, memory impairment, panic attacks, digestive disorders, autoimmune diseases and chronic fatigue syndrome. The modern meaning of stress was laid by Dr. Walter B. Cannon, a physiologist at Harvard almost 100 years ago. He was the first to describe the “fight or flight response” as a series of involuntary physiological and biochemical changes that prepare one to deal with threats of danger. Professor Hans Selye in 1956, first time introduced before the public the concept of stress in a medical sense to indicate the overloading of works on human body. In the 21st century the biggest killer is not AIDS or cancer but psychological problems due to stress. The book discusses the stress and management of stress in some details.