The four nucleotides (bases), A. T. G and C in genomic DNA were sophisticatedly arranged with the following structural-features in a single-strand of DNA, (1) the reverse-complement symmetry of 1-12 successive base sequences, (2) the bias of four bases, (3) the multiple fractality of the distribution of each four bases depending on the distance in double logarithmic plot. These structural features were coexisted regardless species, forms, genome-sizes and GC-contents, i.e., the generation-rule for genome. In viruses and plasmids, the multiple fractality might be occasionally hard to distinguish clearly with the power-low-tail region (multi-fractal dimension) because of the low base numbers. Author showed that (1) the above generation-rule for the biologically active genomic DNA were observed all living cells including the organelle and the virus, (2) the potentiality of a new analytic method of the genome structure based on the appearance frequency, Sequence Spectrum Method could be analyzed DNA, RNA and protein in the cells, (3) the structural features of genome might be related the biological complexity. These findings might be useful extremely to understand the living cells.