Call Us 080-41656200 (Mon-Sat: 10AM-8PM)
Free Shipping above Rs. 1499
Cash On Delivery*

Studies on role of cholesterol in the pathogenesis of prion disorders


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days


Check Your Delivery Options

Rs. 3,651

Availability: In stock

  • Product Description

Several lines of evidence have indicated that prion disorders are associated with an increase in cellular cholesterol content. Our findings highlight the existence of metabolic lipid alterations associated with prion infection. A higher content of cholesterol esters (CE) was accompanied by variations in the expression of ACAT-1 and Cav-1 in skin fibroblasts from scrapie-susceptible sheep. Increased levels and altered distribution of free cholesterol (FC), triglycerides, phospholipids and CEs were found in prion-infected N2a cells (ScN2a). Similar cholesterol alterations were observed in brains of Pravastatin-treated and untreated scrapie-infected mice: a high level of cholesteryl-arachidonate was associated with increased CEs in the brain while oral pravastatin administration caused a significant reduction of FC and an additional increase of CEs. In addition, the treatment with dual-drug combinations of a cholesterol ester modulator with a prion inhibitor had showed a synergistic anti-prion effect in ScN2a cells. These data support our hypothesis that certain pathways of cholesterol/cholesterol ester metabolism may represent suitable targets for prion disease therapy.

Product Specifications
SKU :COC97852
AuthorSarah Vascellari and Alessandra Pani
Number of Pages100
Publishing Year2011-12-16T00:00:00.000
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-18 00:00:00
0 Review(s)