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Study of Few Polysubstituted Piperidone Analogs

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Dipeptidyl Peptidase-IV (DPP-IV) was found to be one of the emerging targets in the field of antidiabetic drug development. In recent years, Piperidone analogs have shown their application in the field of diabetology as observed in the crystallographic structure of DPP-IV. All the ligand molecules were designed considering the pharmacophoric features of the GGO901 (Co-crystallised ligand of DPP-IV with the PDB entry-2OQI). It was thought worthwhile to perform docking study by extracting the crystallographic structure of Dipeptidyl Peptidase-IV inhibitor with all the virtually developed molecules to ensure the better binding energy which would be well able to explain the ligand target interaction of novel piperidone analogs, actively inhibiting DPP-IV enzyme. Based on the docking output, a few novel imidazole linked piperidone analogs were synthesized & as a part of the structure elucidation process various spectroscopic data were collected and subsequently analysed. All the analytically proven synthesized compounds were further sent for biological evaluation.

Product Specifications
SKU :COC31602
AuthorSourav De and Subhasis Banerjee
LanguageEnglish
BindingPaperback
Number of Pages72
Publishing Year12/27/2012
ISBN978-3848404971
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00
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