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Study of the Genotoxic effect of drugs induced genetic damage in mice


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  • Product Description

The micronucleus test (MNT) on mammalian bone marrow is widely accepted as a toxicological screening test used as a sensitive method for measuring genetic damage. The aim of the current study was to evaluate frequency of micronucleated polychromatic erythrocytes in the bone marrow of mice treated with 2-Deoxy -D- Glucose (2DG) and cyclophosphamide (CPH). The mean MnPCE values are found a significant inhibition in micronuclei formation was noticed with Cyclophosphamide 125 mg/kg body weight dose (p > 0.001) to compare with 2 DG and control groups. When we use 2-DG in the MN analysis, it was observed that the 0.5 mg/kg MnPCE level was higher in treated mice as compared to controls. The 1.0 mg/kg MnPCE level was lower. The 2.0 mg/kg MnPCE level also was lower however; the differences were highly significant (p > 0.001). The combination of Cyclophosphamide and 2-Deoxy -D- Glucose 0.5 mg/kg MnPCE level were significantly increased and 1 mg/kg body weight was significantly decreased, overall the combination results were showing (p > 0.001). This study revealed that mice MN assay can be used as a genotoxicological test-system since some methodological particularities were observed.

Product Specifications
SKU :COC99533
AuthorRamakrishnan Veerabathiran
Number of Pages76
Publishing Year2011-12-13T00:00:00.000
Edition1 st
Book TypeGenetics (non-medical)
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-18 00:00:00
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