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Substituted triazolo fused heterocyclic system


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  • Product Description

4-Quinolones comprise a series of synthetic antibacterial agents patterned after nalidixic acid. They have a proven track record over the past several decades for the treatment of bacterial infections. Their unique mechanism of action and bactericidal properties make them attractive therapeutic agents. Despite nearly forty years of research, quinolones still provide new analogues of both scientific and clinical interest. Compounds that are active against resistant strains, with improved pharmacokinetic and safety profiles are goals for current and future research in this area. In this book, you will find the method of synthesis of series of substituted 1,2,4-triazolo[1,5-a]pyrimidines and 1,2,4-triazolo[1,5-a]-1,3,5-triazines as nalidixic acid isosteres. You will also find the results of the in vitro antimicrobial assay of the synthesized compounds against a panel of Gram positive and Gram negative bacteria, and the yeast-like pathogenic fungus Candida albicans. In addition, the DNA-binding affinity of the synthesized compounds was also provided.

Product Specifications
SKU :COC85028
AuthorMariam Ghaly,Said Bayomi and Eman El-Bendary
Number of Pages136
Publishing Year2013-03-27T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00